For research use only. Not for therapeutic Use.
12-Ethyl-9-hydroxycamptothecin（Cat No.:M027186）is a synthetic derivative of camptothecin, a potent alkaloid originally isolated from Camptotheca acuminata. It belongs to the class of topoisomerase I inhibitors and exhibits strong anticancer activity by stabilizing the DNA-topoisomerase I complex, leading to DNA damage and apoptosis in rapidly dividing cells. The addition of an ethyl group at position 12 and a hydroxyl group at position 9 enhances its cytotoxic potency and pharmacokinetic properties. This compound shows promise in preclinical cancer research, particularly against solid tumors, and serves as a lead molecule for novel chemotherapeutic drug development.
| CAS Number | 119577-28-5 |
| Synonyms | (19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione |
| Molecular Formula | C22H20N2O5 |
| Purity | ≥95% |
| IUPAC Name | (19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione |
| InChI | InChI=1S/C22H20N2O5/c1-3-11-5-6-17(25)13-7-12-9-24-16(19(12)23-18(11)13)8-15-14(20(24)26)10-29-21(27)22(15,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1 |
| InChIKey | KWUQFLSWWSXTSZ-QFIPXVFZSA-N |
| SMILES | CCC1=C2C(=C(C=C1)O)C=C3CN4C(=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)C3=N2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
