1,1,3,3-Tetramethylguanidine

• CAT Number: R059041
• CAS Number: 80-70-6
• Molecular Formula: C5H13N3
• Molecular Weight: 115.18
• Purity: ≥95%
• Synonyms: N,N,N’,N’-Tetramethylguanidine; N1,N1,N3,N3-Tetramethylguanidine; NSC 148309
• Storage: Store at +4C
• IUPAC Name: 1,1,3,3-tetramethylguanidine
• InChI: InChI=1S/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3
• InChIKey: KYVBNYUBXIEUFW-UHFFFAOYSA-N
• SMILES: CN(C)C(=N)N(C)C

1,1,3,3-Tetramethylguanidine (Cat No.:R059041) is a strong, non-nucleophilic organic base with the molecular formula C5H13N3. It appears as a colorless to pale yellow liquid and is widely used in organic synthesis, particularly in deprotonation reactions and as a catalyst for acylation, alkylation, and condensation processes. Its high basicity and low nucleophilicity make it ideal for promoting selective transformations without side reactions. TMG is also employed in polymer chemistry and peptide synthesis. Due to its volatility and hygroscopic nature, it is typically handled under inert conditions and stored away from moisture and air.