1,1,1,3,3,3-Hexafluoro-2-propanol

• CAT Number: R040943
• CAS Number: 920-66-1
• Molecular Formula: C3H2F6O
• Molecular Weight: 168.04
• Purity: ≥95%
• Synonyms: 1,1,1,3,3,3-Hexafluoro-2-hydroxypropane; 1,1,1,3,3,3-Hexafluoroisopropanol; 1,1,1,3,3,3-Hexafluoroisopropyl Alcohol; 1,1,1,3,3,3-Hexafluoropropanol; 2,2,2-Trifluoro-1-(trifluoromethyl)ethanol; Bis(trifluoromethyl)methanol; HFIP; Hexafluoroisopropanol
• Storage: -20°C
• IUPAC Name: 1,1,1,3,3,3-hexafluoropropan-2-ol
• InChI: InChI=1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
• InChIKey: BYEAHWXPCBROCE-UHFFFAOYSA-N
• SMILES: C(C(F)(F)F)(C(F)(F)F)O

1,1,1,3,3,3-Hexafluoro-2-propanol (CAT: R040943) is a highly fluorinated secondary alcohol with the molecular formula C₃H₂F₆O. It appears as a colorless liquid with a strong, sharp odor and is completely miscible with water and many organic solvents. Known for its strong hydrogen-bond-donating ability, high polarity, and volatility, HFIP is widely used as a specialty solvent in organic synthesis, polymer processing, and peptide chemistry. It can stabilize reactive intermediates, dissolve otherwise insoluble materials, and influence reaction selectivity. Additionally, HFIP is employed in spectroscopic studies, as an additive in chromatography, and in materials research to modify surface properties or enhance polymer performance.