1,1’-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenyl-phosphine

• CAT Number: R043197
• CAS Number: 161265-03-8
• Molecular Formula: C39H32OP2
• Molecular Weight: 578.63
• Purity: ≥95%
• Synonyms: (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[diphenyl-phosphine; (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[diphenylphosphine]; 4,5-Bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene; 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene; 9,9-Dimethyl-4,5-bis(diphenylp
• Storage: -20°C
• IUPAC Name: (5-diphenylphosphanyl-9,9-dimethylxanthen-4-yl)-diphenylphosphane
• InChI: InChI=1S/C39H32OP2/c1-39(2)33-25-15-27-35(41(29-17-7-3-8-18-29)30-19-9-4-10-20-30)37(33)40-38-34(39)26-16-28-36(38)42(31-21-11-5-12-22-31)32-23-13-6-14-24-32/h3-28H,1-2H3
• InChIKey: CXNIUSPIQKWYAI-UHFFFAOYSA-N
• SMILES: CC1(C2=C(C(=CC=C2)P(C3=CC=CC=C3)C4=CC=CC=C4)OC5=C1C=CC=C5P(C6=CC=CC=C6)C7=CC=CC=C7)C

1,1’-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine](CAT: R043197), commonly known as Xantphos, is a bidentate diphosphine ligand with a large natural bite angle (~108°), making it highly effective in transition metal-catalyzed reactions. Its rigid xanthene backbone and bulky diphenylphosphine arms provide excellent chelation stability and promote unique steric and electronic properties ideal for catalysis. Xantphos is particularly useful in C–C and C–N cross-coupling reactions, including Suzuki, Heck, and Buchwald–Hartwig couplings, often improving reaction rates and selectivity. Its performance with palladium and other late transition metals makes it a favored ligand in both academic and industrial synthesis.