10-Deacetylbaccatin-III

• CAT Number: A000200
• CAS Number: 32981-86-5
• Molecular Formula: C29H36O10
• Molecular Weight: 544.60
• Purity: ≥95%
• Synonyms: 32981-86-5; UNII-4K6EWW2Z45; 10-Deacetylbaccatin; CHEBI:18193; 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate
• Target: Disease Research Fields
• Solubility: >22.3mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18-,19+,21+,22-,24-,27+,28-,29+/m0/s1
• InChIKey: YWLXLRUDGLRYDR-ZHPRIASZSA-N
• SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)O

10-Deacetylbaccatin III (Cat No.: A000200) is a naturally occurring diterpenoid isolated from the needles of Taxus species (yew trees). It serves as a crucial intermediate in the semi-synthesis of the anti-cancer drug paclitaxel (Taxol) and its analogs. Structurally, it retains the core taxane skeleton necessary for microtubule stabilization. Unlike paclitaxel, it lacks the C-13 side chain, which is later added during synthesis. Due to its availability and role in sustainable taxane production, it is widely used in pharmaceutical research and drug development.

Reference

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