1-Tetralol, (S)-（Cat No.:I006733）, is a bioactive chemical compound with potential pharmacological properties. It is a chiral molecule, with the (S)-configuration indicating its stereochemical arrangement. 1-Tetralol is known for its diverse biological activities and has been investigated for its potential therapeutic applications. However, specific details about its exact biological effects or targets may depend on the context of its application, as further research is needed to fully elucidate its mechanisms of action and potential uses in various fields such as medicine, chemistry, or biology.
| Catalog Number | I006733 |
| CAS Number | 53732-47-1 |
| Synonyms | 1-Tetralol, (S)-; (S)-Tetralin-1-ol; J330.337C; (S)-1-Hydroxytetralin;;(S)-1,2,3,4-tetrahydronaphthalen-1-ol |
| Molecular Formula | C10H12O |
| Purity | 95% |
| Solubility | Soluble in DMSO |
| IUPAC Name | (1S)-1,2,3,4-tetrahydronaphthalen-1-ol |
| InChI | InChI=1S/C10H12O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10-11H,3,5,7H2/t10-/m0/s1 |
| InChIKey | JAAJQSRLGAYGKZ-JTQLQIEISA-N |
| SMILES | C1CC(C2=CC=CC=C2C1)O |
| Reference | </br>1: Świzdor A, Janeczko T, Dmochowska-Gładysz J. Didymosphaeria igniaria: a new microorganism useful for the enantioselective reduction of aryl-aliphatic ketones. J Ind Microbiol Biotechnol. 2010 Nov;37(11):1121-30. doi: 10.1007/s10295-010-0759-9. Epub 2010 Jun 11. PubMed PMID: 20544255.</br>2: Penick MA, Mahindaratne MP, Gutierrez RD, Smith TD, Tiekink ER, Negrete GR. Tandem Friedel-Crafts annulation to novel perylene analogues. J Org Chem. 2008 Aug 15;73(16):6378-81. doi: 10.1021/jo800558c. Epub 2008 Jul 16. PubMed PMID: 18630879; PubMed Central PMCID: PMC4780845.</br>3: Bichlmaier I, Siiskonen A, Kurkela M, Finel M, Yli-Kauhaluoma J. Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17. Biol Chem. 2006 Apr;387(4):407-16. PubMed PMID: 16606339.</br>4: Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis. Biochemistry. 2005 Dec 27;44(51):16875-85. PubMed PMID: 16363801.</br>5: Fujio M, Keeffe JR, More O’Ferrall RA, O’Donoghue AC. Unexpectedly small ortho-oxygen substituent effects on stabilities of benzylic carbocations. J Am Chem Soc. 2004 Aug 18;126(32):9982-92. PubMed PMID: 15303872.</br>6: Jung JC, Kim JC, Park OS, Jang BS. Synthesis of 4-hydroxy-1-thiocoumarin derivatives-1: an efficient synthesis of thioflocoumafen. Arch Pharm Res. 1999 Jun;22(3):302-5. PubMed PMID: 10403135.</br>7: Grayson DA, Tewari YB, Mayhew MP, Vilker VL, Goldberg RN. Tetralin as a substrate for camphor (cytochrome P450) 5-monooxygenase. Arch Biochem Biophys. 1996 Aug 15;332(2):239-47. PubMed PMID: 8806731.</br>8: Grunewald GL, Ye Q, Sall DJ, Criscione KR, Wise B. Conformational and steric aspects of phenylethanolamine and phenylethylamine analogues as substrates or inhibitors of phenylethanolamine N-methyltransferase. Mol Pharmacol. 1989 Jan;35(1):93-7. PubMed PMID: 2913486.</br>9: Grunewald GL, Ye QH. Stereochemical aspects of phenylethanolamine analogues as substrates of phenylethanolamine N-methyltransferase. J Med Chem. 1988 Oct;31(10):1984-6. PubMed PMID: 3172133.</br>10: Matos FF, Lippman DA, Malone MH. Opioid receptor effects of two 3-amino-2,2-dimethyltetralin analogs in guinea pig ileum longitudinal muscle. NIDA Res Monogr. 1986;75:217-9. PubMed PMID: 3123938. </br> </br> |
