(1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid

• CAT Number: L044828
• CAS Number: 1000068-26-7
• Molecular Formula: C13H15BFNO4
• Molecular Weight: 279.07
• Purity: ≥95%
• IUPAC Name: [6-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-2-yl]boronic acid
• InChI: InChI=1S/C13H15BFNO4/c1-13(2,3)20-12(17)16-10-7-9(15)5-4-8(10)6-11(16)14(18)19/h4-7,18-19H,1-3H3
• InChIKey: GARRUKBUEWVRCV-UHFFFAOYSA-N
• SMILES: B(C1=CC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2)F)(O)O

(1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid(CAT: L044828) is a multifunctional indole-based building block bearing a boronic acid group at the 2-position, a fluorine substituent at the 6-position, and a Boc-protected nitrogen. This compound is particularly suited for Suzuki–Miyaura cross-coupling reactions, enabling the synthesis of diverse fluorinated indole derivatives. The Boc group provides protection during multi-step synthesis, allowing selective deprotection when needed. Its fluorine atom enhances metabolic stability and modulates electronic properties, making it valuable in medicinal chemistry for designing kinase inhibitors, CNS-active agents, and other drug-like molecules. This reagent is ideal for structure–activity relationship studies and late-stage functionalization in pharmaceutical research.