1-NM-PP1

  • CAT Number: I002695
  • CAS Number: 221244-14-0
  • Molecular Formula: C20H21N5
  • Molecular Weight: 331.4
  • Purity: ≥95%
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1-NM-PP1 (CAT: I002695), also known as PP1 Analog II, is a cell-permeable compound with significant implications in kinase inhibition. It serves as a potent and selective inhibitor of mutant kinases compared to their wild-type counterparts. Notably, 1-NM-PP1 effectively targets and inhibits the activity of mutant kinases, such as v-Src (IC50 = 28 μM) and v-Src-as1 I338G (IC50 = 4.2 nM). This inhibitor’s selectivity for mutant kinases over wild-type forms underscores its potential importance in cancer research and personalized medicine, where targeting specific kinase mutations can offer innovative therapeutic strategies for disease treatment and intervention.

Catalog Number I002695
CAS Number 221244-14-0
Molecular Formula

C20H21N5

Purity 95%
Target Src
Solubility DMSO: ≤ 27.5 mg/mL
Storage Store at -20C
IC50 4.2 nM (v-Src-as1 I338G) [1]
InChI InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)
InChIKey GDQXJQSQYMMKRA-UHFFFAOYSA-N
SMILES NC1=NC=NC2=C1C(CC3=CC=CC4=C3C=CC=C4)=NN2C(C)(C)C
Reference

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<br>[1]. Papa FR, et al. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28;302(5650):1533-7.
<br>[2]. Larochelle S, et al. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell. 2007 Mar 23;25(6):839-50.
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