Platelet-<wbr></wbr>activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy. PAF is converted to the biologically inactive lyso-<wbr></wbr>PAF by the enzyme PAF acetylhydrolase (PAF-<wbr></wbr>AH). Recently, plasma PAF-<wbr></wbr>AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans. 1-<wbr></wbr>Linoleoyl glycerol (1-<wbr></wbr>LG) is a fatty acid glycerol that has been isolated from <em>S. chinensis</em> roots. It inhibits PAF-<wbr></wbr>AH with an IC<sub>50</sub> of 45 µM. 1-<wbr></wbr>LG has potential application in cholesterol lowering and antiatherogenic activity.
| Catalog Number | R001609 |
| CAS Number | 2277-28-3 |
| Synonyms | (9Z,12Z)-9,12-Octadecadienoic Acid 2,3-Dihydroxypropyl Ester; 1-Glyceryl Linoleate; 1-Linoleylglycerol; 1-Monolinolein; 1-Monolinoleoyl-rac-glycerol; Glycerol 1-Monolinolate; Oleinate 288; α-Glyceryl linoleate; α-Monolinolein; ? |
| Molecular Formula | C21H38O4 |
| Purity | 95% |
| Storage | -80°C |
| InChIKey | WECGLUPZRHILCT-HZJYTTRNSA-N |
