1-Isocyano-2-methoxy-2-methyl-propane

• CAT Number: R060570
• CAS Number: 109434-22-2
• Molecular Formula: C6H11NO
• Molecular Weight: 113.16
• Purity: ≥95%
• Synonyms: 2-Methoxyisobutyl isocyanide; 2-Methoxyisobutyl isonitrile; MIBI
• Storage: -20°C
• IUPAC Name: 1-isocyano-2-methoxy-2-methylpropane
• InChI: InChI=1S/C6H11NO/c1-6(2,8-4)5-7-3/h5H2,1-2,4H3
• InChIKey: LJJFNFYPZOHRHM-UHFFFAOYSA-N
• SMILES: CC(C)(C[N+]#[C-])OC

1-Isocyano-2-methoxy-2-methyl-propane（Cat No.:R060570）, also known as tert-butyl isocyanide methyl ether, is an organic compound with the molecular formula C6H11NO. It features an isocyanide functional group attached to a branched, sterically hindered carbon center bearing both methoxy and methyl groups. This compound is commonly used in multicomponent reactions such as the Ugi and Passerini reactions, where isocyanides act as key nucleophilic components in building complex molecular scaffolds. Its bulky structure influences reaction selectivity, making it valuable in medicinal chemistry and combinatorial synthesis for creating libraries of bioactive molecules and drug-like candidates.