1-Iodo-2-(trifluoromethoxy)benzene

• CAT Number: M039573
• CAS Number: 175278-00-9
• Molecular Formula: C7H4F3IO
• Molecular Weight: 288.01
• Purity: ≥95%
• Storage: Store at -20C
• IUPAC Name: 1-iodo-2-(trifluoromethoxy)benzene
• InChI: InChI=1S/C7H4F3IO/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4H
• InChIKey: GYBMJVZOZTVDKS-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)OC(F)(F)F)I

1-Iodo-2-(trifluoromethoxy)benzene（Cat No.:M039573）is an aromatic halide featuring an iodine atom at the 1-position and a trifluoromethoxy (-OCF₃) group at the 2-position of a benzene ring. The presence of iodine makes it highly reactive in cross-coupling reactions such as Suzuki, Sonogashira, and Buchwald–Hartwig, enabling the construction of complex organic molecules. The trifluoromethoxy group imparts strong electron-withdrawing properties and enhances metabolic stability, lipophilicity, and bioavailability in drug candidates. This compound is widely utilized in medicinal chemistry, agrochemical development, and material science for introducing fluorinated aryl structures with tailored physicochemical properties.