1-Fluoronaphthalene

• CAT Number: R052924
• CAS Number: 321-38-0
• Molecular Formula: C10H7F
• Molecular Weight: 146.16
• Purity: ≥95%
• Synonyms: NSC 4690; α-Fluoronaphthalene; Duloxetine USP Impurity G
• Storage: -20°C
• IUPAC Name: 1-fluoronaphthalene
• InChI: InChI=1S/C10H7F/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H
• InChIKey: CWLKTJOTWITYSI-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=CC=C2F

1-Fluoronaphthalene(CAT: R052924) is a fluorinated aromatic hydrocarbon featuring a fluorine atom substituted at the 1-position of the naphthalene ring system. This compound is a valuable intermediate in organic synthesis, particularly in the development of agrochemicals, pharmaceuticals, and advanced materials. The electron-withdrawing fluorine enhances the reactivity of the aromatic ring, facilitating regioselective transformations and cross-coupling reactions such as Suzuki and Buchwald–Hartwig couplings. 1-Fluoronaphthalene is also used in structure–activity relationship (SAR) studies to modify molecular properties like lipophilicity and metabolic stability.