1-(Cyclopropylcarbonyl)piperazine

• CAT Number: L025681
• CAS Number: 59878-57-8
• Molecular Formula: C8H14N2O
• Molecular Weight: 154.21
• Purity: ≥95%
• IUPAC Name: cyclopropyl(piperazin-1-yl)methanone
• InChI: InChI=1S/C8H14N2O/c11-8(7-1-2-7)10-5-3-9-4-6-10/h7,9H,1-6H2
• InChIKey: KIALFUYSJAAJSU-UHFFFAOYSA-N
• SMILES: C1CC1C(=O)N2CCNCC2

1-(Cyclopropylcarbonyl)piperazine（Cat No.:L025681）is a nitrogen-containing heterocyclic compound featuring a piperazine ring substituted at the nitrogen atom with a cyclopropylcarbonyl group. The cyclopropyl moiety introduces ring strain and hydrophobic character, which can enhance membrane permeability and metabolic stability in drug candidates. This compound is frequently used as an intermediate in medicinal chemistry for synthesizing pharmaceutical agents, especially those targeting the central nervous system or acting as enzyme inhibitors. Its dual nitrogen atoms enable further functionalization, while the cyclopropylcarbonyl group modulates electronic and steric properties for structure–activity relationship (SAR) exploration.