1-Acetyl-4-(4-hydroxyphenyl)piperazine

• CAT Number: R004358
• CAS Number: 67914-60-7
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.27
• Purity: ≥95%
• Synonyms: 1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone; 4-(4-Acetylpiperazino)phenol; 1-Acetyl-4-(p-hydroxyphenyl)piperazine; Ketoconazole Intermediate (branched chain of ketoconazole)
• Storage: Store at -20°C
• IUPAC Name: 1-[4-(4-hydroxyphenyl)piperazin-1-yl]ethanone
• InChI: InChI=1S/C12H16N2O2/c1-10(15)13-6-8-14(9-7-13)11-2-4-12(16)5-3-11/h2-5,16H,6-9H2,1H3
• InChIKey: AGVNLFCRZULMKK-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCN(CC1)C2=CC=C(C=C2)O

1-Acetyl-4-(4-hydroxyphenyl)piperazine（Cat No.:R004358）is a substituted piperazine derivative featuring an acetyl group on one nitrogen atom and a para-hydroxyphenyl group on the opposite nitrogen. This bifunctional molecule combines aromatic and aliphatic elements, offering hydrogen bonding and moderate lipophilicity. The phenolic hydroxyl group contributes to potential antioxidant or receptor-binding properties, while the piperazine ring is commonly found in bioactive compounds. It serves as a valuable intermediate in medicinal chemistry, particularly in the design of central nervous system (CNS)-active agents, receptor modulators, or pharmacophores targeting neurotransmitter systems and psychiatric disorders.