1-((2,4,6-Triisopropylphenyl)sulfonyl)-1H-imidazole

• CAT Number: L042867
• CAS Number: 50257-40-4
• Molecular Formula: C18H26N2O2S
• Molecular Weight: 334.50
• Purity: ≥95%
• IUPAC Name: 1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylimidazole
• InChI: InChI=1S/C18H26N2O2S/c1-12(2)15-9-16(13(3)4)18(17(10-15)14(5)6)23(21,22)20-8-7-19-11-20/h7-14H,1-6H3
• InChIKey: AGGRGODMKWLSDE-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC(=C(C(=C1)C(C)C)S(=O)(=O)N2C=CN=C2)C(C)C

1-((2,4,6-Triisopropylphenyl)sulfonyl)-1H-imidazole（Cat No.:L042867）is a sterically hindered sulfonylimidazole used in organic synthesis as a sulfonylating agent and activating group. The bulky 2,4,6-triisopropylphenyl (TRIP) group provides both steric protection and enhanced selectivity, making this compound valuable in reactions requiring controlled reactivity or regioselectivity. It is commonly used in peptide synthesis, heterocycle formation, and the generation of reactive intermediates. The imidazole moiety contributes to good leaving group ability, facilitating nucleophilic substitution reactions. This reagent is particularly favored in complex molecule construction and fine-tuning reaction conditions in medicinal and synthetic chemistry.