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α-Tocopheryl Succinate

α-Tocopheryl Succinate

  • CAT Number: R053041
  • CAS Number: 4345-03-3
  • Molecular Formula: C33H54O5
  • Molecular Weight: 530.79
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">&alpha;-Tocopheryl Succinate (CAS&nbsp;4345-03-3)&nbsp;<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">is an analogue of alpha-tocopherol (vitamin E) with unique biological properties.&nbsp;</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Its ability to prolong cell cycle arrest, induce apoptosis, and act as a radiosensitizer make it a compound of great interest in integrative cancer care.</span></span></span></span>

Catalog Number R053041
CAS Number 4345-03-3
Molecular Formula

C33H54O5

Purity 95%
Storage -20°C
IUPAC Name 4-oxo-4-[[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid
InChI InChI=1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1
InChIKey IELOKBJPULMYRW-NJQVLOCASA-N
SMILES CC1=C2C(=C(C(=C1C)OC(=O)CCC(=O)O)C)CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C
Reference

<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Neuzil, J., et al. &quot;Selective cancer cell killing by &alpha;-tocopheryl succinate.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">British journal of cancer</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;84.1 (2001): 87-89.<br />
2.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Prasad, Kedar N., et al. &quot;&alpha;-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Journal of the American College of Nutrition</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;22.2 (2003): 108-117.<br />
3.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Neuzil, Jiri, et al. &quot;&alpha;-Tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Biochemical Journal</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;362.3 (2002): 709-715.</span></span></span>

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