γ-Lipoic Acid

  • CAT Number: R018565
  • CAS Number: 462-20-4
  • Molecular Formula: C8H16O2S2
  • Molecular Weight: 208.334
  • Purity: ≥95%
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Dihydrolipoic acid (DHLA; CAS 462-20-4) is a dithiol-<wbr />containing carboxylic acid that is the reduced form of &alpha;-lipoic acid. It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including hydroxyl radicals, peroxynitirite, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM. At concentrations of 50-100 &micro;M, DHLA triggers apoptosis of mouse embryonic stem cells and human cancer cells, suppressing proliferation.

Catalog Number R018565
CAS Number 462-20-4
Synonyms

6,8-Dimercaptooctanoic Acid; (±)-Dihydro-α-lipoic Acid; (±)-Dihydrolipoic Acid; DL-Dihydro-α-lipoic Acid; Dihydrolipoic Acid; Dihydrothioctic Acid; Reduced Lipoic Acid; Reduced Thioctic Acid; Dihydrothioctic Acid; dl-Dihydrolipoic Acid;

Molecular Formula

C8H16O2S2

Purity 95%
Storage -20°C
IUPAC Name 6,8-bis(sulfanyl)octanoic acid
InChI InChI=1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)
InChIKey IZFHEQBZOYJLPK-UHFFFAOYSA-N
SMILES C(CCC(=O)O)CC(CCS)S
Reference

<p>
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Moini, Hadi, Lester Packer, and Nils-Erik L. Saris. &quot;Antioxidant and prooxidant activities of &alpha;-lipoic acid and dihydrolipoic acid.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Toxicology and applied pharmacology</i>&nbsp;182.1 (2002): 84-90.<br />
2.Houng, Wei-Li, et al. &quot;Dihydrolipoic acid induces cytotoxicity in mouse blastocysts through apoptosis processes.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">International journal of molecular sciences</i>&nbsp;13.3 (2012): 3988-4002.</span></span></span></p>

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