β-Elemene is a natural sesquiterpene found in various plants and imparts floral aromas to some plants. This compound has been reported to inhibit the proliferation of a wide range of tumors. In HepG2 cells, 10-40 µg/ml β-elemene can dose-dependently induce apoptosis and cell cycle arrest in the G<sub>2</sub>/M phase, upregulating Fas/FasL expression. It has been shown to enhance the sensitivity of Hep3B, Hu7, MHCC97H, and MHCCLM3 cells to oxaliplatin (Item No. <span class=/itemid/>13106</span>; IC<sub>50</sub>s = 1.79, 3.27, 2.54, and 5.73 µM, respectively) by upregulating copper transporter 1, a major regulator of intracellular platinum accumulation.
| Catalog Number | R066610 |
| CAS Number | 515-13-9 |
| Synonyms | (-)-β-Elemene;Levo-β-elemene |
| Molecular Formula | C15H24 |
| Purity | 95% |
| Storage | -20°C |
| InChI | InChI=1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3/t13-,14+,15-/m1/s1 |
| InChIKey | OPFTUNCRGUEPRZ-QLFBSQMISA-N |
| SMILES | C=C[C@@]1(C)[C@H](C(C)=C)C[C@H](C(C)=C)CC1 |
| Reference | 1.Chen, M.,Zhang, J.,Yu, S., et al. Anti-lung-cancer activity and liposome-based delivery systems of β-elemene. Evidence-Based Complementary and alternative Medicine 2012:259523, (2012). |
