CC-885 (Cat.No:I005886) is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1. was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 (also named eRF3a) is a translation termination factor that binds eukaryotic translation termination factor 1 (eFR1) to mediate stop codon recognition and nascent protein release from the ribosome.
| Catalog Number | I005886 |
| CAS Number | 1010100-07-8 |
| Synonyms | CC-885, CC 885, CC885.;N-(3-chloro-4-methylphenyl)-N/’-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea |
| Molecular Formula | C22H21ClN4O4 |
| Purity | 0% |
| Target | Cereblon Modulator |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 1-(3-chloro-4-methylphenyl)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea |
| InChI | InChI=1S/C22H21ClN4O4/c1-12-2-4-15(9-17(12)23)25-22(31)24-10-13-3-5-16-14(8-13)11-27(21(16)30)18-6-7-19(28)26-20(18)29/h2-5,8-9,18H,6-7,10-11H2,1H3,(H2,24,25,31)(H,26,28,29) |
| InChIKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
| SMILES | O=C1NC(CCC1N2C(C(C=CC(CNC(NC3=CC(Cl)=C(C)C=C3)=O)=C4)=C4C2)=O)=O |
| Reference | 1:Cancer Discov. 2016 Aug;6(8):OF15. doi: 10.1158/2159-8290.CD-RW2016-123. Epub 2016 Jul 1. The Cereblon Modulator CC-885 Exhibits Antitumor Activity. PMID: 27369046 DOI: 10.1158/2159-8290.CD-RW2016-123 </br><span>Abstract:</span> A common motif likely promotes binding of substrates, including GSPT1, to cereblon. ©2016 American Association for Cancer Research. |
