p38 MAPK

p38 MAPK

The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes is achieved with an apparently simple linear architecture of the pathway, consisting of a core of three protein kinases acting sequentially.

An Overview of p38 MAPK

Mitogen-activated protein kinase (MAPK) is a kind of serine/threonine protein kinase. It has been demonstrated that MAPKs signal transduction pathway exists in most cells and transducts extracellular stimulation signals into the cells and their nuclei. MAPKs signal transduction pathway is highly conserved in cell evolution. Multiple parallel MAPKs have been found in both low prokaryotic cells and higher mammalian cells. Different extracellular stimuli can use different MAPKs signaling pathways and mediate different cellular biological responses through their mutual regulation.

Major types of p38 MAPK

MAPK consists of four subfamilies. The first three subfamilies are , apoptosis, cell cycle, myocardial hypertrophy, development, cell differentiation, aging and tumor inhibition. The production of growth factors, adhesion molecules and other inflammatory factors such as COX, inducible nitric oxide synthase, interleukin 10 (IL-10) depends on the regulation of p38 pathway. The p38 pathway can also be activated by inflammatory factors such as tumor necrosis factor a (TNF-a) and IL-1. And it also has regulation functions for cell proliferation and differentiation in the immune system.


1. Wang Guojun, Liu Yawei, Li Yuhua, Jiangyong.p38 mitogen-activated protein kinase inhibitors [J].Biotechnology Communication, 2009,20 (03): 399-403.

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