Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a protein that in humans is encoded by the MALT1 gene. MALT1 is part of the paracaspase family and shows proteolytic activity. Since many of the substrates are involved in regulation of inflammatory responses, the protease activity of MALT1 has emerged as an interesting therapeutic target.

An overview of MALT1

Mucosa-associated lymphoid lymphoma translocation protein 1 (MALT1), encoded by MALT1 gene, belongs to the paracaspase family. MALT1 has great influence on immunity, inflammation and lymphoid malignances by activating immune cells. . For example, MALT1 could be detected in advanced stages of MALT1 for the linkage to oncogenic protein encoded by a chromosomal translocation. In the future, research on MALT1 will focus more on its molecular function and figure out the full spectrum of its substrates.


1. Jaworski, M. & Thome, M. The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cellular & Molecular Life Sciences 73, 459-473 (2016).

2. Demeyer, A., Staal, J. & Beyaert, R. Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad? Trends in molecular medicine 22, 135-150 (2016).

3. Mcallisterlucas, L. M., Baens, M. & Lucas, P. C. MALT1 protease: a new therapeutic target in B-lymphoma and beyond? Clinical Cancer Research An Official Journal of the American Association for Cancer Research 17, 6623 (2011).

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