An Overview of HCV
Hepatitis C virus (HCV) is a global public health problem since its discovery in 1989, affecting about 3% of the world’s population. The spread of HCV is caused by blood-to-blood fluids and other methods, such as mother-to-child transmission and sexual transmission. HCV is a viral envelope of a single strand RNA genome about 9.6 kb genome long and contains a long open reading frame made up of 5’ noncoding region (NCR) that starts part of the translation, downstream of open reading frame (ORF) and 3’-NCR that are key parts of HCV replication.
Major types of HCV
The HCV has six major types, such as type 1, 2, 3, 4, 5, and 6. The incidence of different types of HCV is different in different regions. For example, in Mexico, the most common genotype appeared order was type 1 (69%), 2 (21.4%), and 3 (9.2%). Type 4 and 5 are rare. However, there is no subject that infects type 6. Moreover, the type 1 and 2 exhibit very similar distributions in all geographical regions.
Inhibition of HCV
HCV infections include viral particle intrusion, viral genome translation and replication, and the assembly and release of mature viral particles. Anti-HCV drugs have developed rapidly in recent years, and the new type of HCV inhibitor significantly improves the patient's continued viral response (Sustained virological response rate, SVR rate). Current antiviral therapies for HCV include poly (ethylene glycol) interferon alpha (Pegylated interferon alpha, peg-IFN-α), , , etc., which are recommended for genotype 1 HCV infection, and can improve the cure rate.
HCV and diseases
Persistent infection of HCV can cause chronic hepatitis, liver cirrhosis and liver cancer. The degree of chronic infection is very high, and the progression of disease is concealed. End stage patient are often accompanied by chronic liver diseases, including fatty degeneration of liver, liver fibrosis, and even liver cancer. At present, there is no effective prophylactic or therapeutic vaccine available.
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Products for HCV