HBV

HBV

Hepatitis B virus (HBV) is the smallest hepadnavirus of about 42 nm in diameter, which has a partially double-stranded circular DNA genome of 3.2 kb. The viral genome together with the viral polymerase are packed inside the nucleocapsid core (HBeAg), surrounded by an outer lipoprotein coat (envelope) containing the surface antigen (HBsAg). Compared to other human viruses, HBV is unusual in that it contained a vast excess of noninfectious subviral particles composed only of viral surface proteins and lipids, appear predominantly as 22 nm spheres and filaments with a diameter of 22 nm.

An Overview of HBV

Hepatitis B virus (HBV) infection is a worldwide epidemic and an important health problem in the world. Now, there are 3 kinds of HBV transmission methods: menstrual blood transmission, mother-to-child transmission and sexual transmission. Clinically, the main HBV manifestations are loss of appetite, nausea, liver pain and weakness were clinically. For the HBV structure, three types of viral particles were observed by electron microscopy in infectious serum, which were 42 nm in diameter (Dane particle-Virion), 20 nm in diameter (Spherical Structures), 22 nm in diameter (Filamentous Particles). HBV is the double-stranded circular DNA genome of about 42 nm in diameter. The viral genome together with the viral polymerase are packed inside the nucleocapsid core Hepatitis B e antigen (HBeAg), surrounded by an outer lipoprotein coat (envelope) containing the Hepatitis B surface antigen (HBsAg).

Major types of HBV

The HBV was divided into four main serum types (ADR, ADW, El, YAW) according to the table of the membrane protein. And based on the variation of total nucleotide sequence of genome, it was divided into eight genotypes (A-H).

Inhibition of HBV

are used for the treatment of chronic HBV. In addition, Adefovir Dipivoxil blocks HBV reverse transcriptase. According to some other reports, it’ s the chemical structure of reported HBV capsid inhibitors that was found to be potent against HBV replication in various human hepatoma cell lines.

HBV and diseases

There are three major disease types of HBV. First, according to the duration of the disease classification, it can be divided into acute and chronic HBV. Second, according to the severity of the disease classification, it can be divided into hepatitis B carriers, active hepatitis B, severe hepatitis, hepatitis cirrhosis. Third, according to the presence of jaundice, it can be divided into jaundice type and no jaundice type.

References:

Liang TJ. (2009). Hepatitis B: the virus and disease. Hepatology, 49(S5), S13-S21.

Hu Yimin. (2013). Novel Therapeutics in Discovery and Development for Treatment of Chronic HBV Infection. Annual ReportsinMedicinal Chemistry, 48, 265-281.

Ren Q. (2017). Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4). BIOORGANIC & MEDICINAL CHEMISTRY,25(3), 1042-1056.

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