An IκB kinase is an enzyme that catalyzes the chemical reaction: ATP + IκB protein ADP + IκB phosphoprotein. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade.

An overview of IKK

Nuclear factor-kappa B ( , atherosclerosis and acquired immunedeficiency syndrome (AIDS). Hence, targeting IKK and blocking signaling pathways of NF-κB is proved to be useful in the treatment of inflammation and other diseases.


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3. Shen, R. R. & Hahn, W. C. Emerging roles for the non-canonical IKKs in cancer. Oncogene 30, 631-641, doi:10.1038/onc.2010.493 (2011).

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