IKK

IKK

An IκB kinase is an enzyme that catalyzes the chemical reaction: ATP + IκB protein ADP + IκB phosphoprotein. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade.

An overview of IKK

Nuclear factor-kappa B ( , atherosclerosis and acquired immunedeficiency syndrome (AIDS). Hence, targeting IKK and blocking signaling pathways of NF-κB is proved to be useful in the treatment of inflammation and other diseases.

References:

1. Scheidereit, C. I kappa B kinase complexes: gateways to NF-kappa B activation and transcription. Oncogene 25, 6685-6705, doi:10.1038/sj.onc.1209934 (2006).

2. Karin, M., Yamamoto, Y. & Wang, Q. M. The IKKNF-kappa B system: A treasure trove for drug development. Nature Reviews Drug Discovery 3, 17-26, doi:10.1038/nrd1279 (2004).

3. Shen, R. R. & Hahn, W. C. Emerging roles for the non-canonical IKKs in cancer. Oncogene 30, 631-641, doi:10.1038/onc.2010.493 (2011).

4. Kim, H. J., Hawke, N. & Baldwin, A. S. NF-kappa B and IKK as therapeutic targets in cancer. Cell Death Differ. 13, 738-747, doi:10.1038/sj.cdd.4401877 (2006).

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