COX

COX

Nonsteroidal anti-inflammatory drugs (NSAIDs) are beneficial in the treatment and prevention of Alzheimer's disease (AD). NSAIDs act by inhibiting cyclooxygenase (COX), an enzyme that occurs in constitutive and inducible isoforms, known respectively as COX-1 and COX-2. Recognition that COX-2 plays a key role in inflammation led to the hypothesis that COX-2 might represent the primary target for NSAIDs in AD, consistent with inflammatory processes occurring in AD brain.

The two isoforms of the COX enzyme, COX-1 and COX-2, are coded by the COX-1 and COX-2 gene, respectively. These two isoenzymes share about 60% gene homology; however, substantial differences exist between the gene and promoter structures of COX-1 and COX-2. The two isoforms of the COX enzyme, COX-1 and COX-2, are coded by the COX-1 and COX-2 gene, respectively. These two isoenzymes share about 60% gene homology; however, substantial differences exist between the gene and promoter structures of COX-1 and COX-2.

Historically, is approximately 30 times more potent at inhibiting COX-2 than COX-1.

Reference:Timothy D. Brunson . EFFECT OF CYCLOOXYGENASE INHIBITORS ON RAT ROOT RESORPTION AND TOOTH MOVEMENT

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