p97

p97

p97 knows also as VCP ( Cdc48 in yeast) is a hexameric ATPase of the AAA family which disassembles SNARE proteins after membrane fusion.[1] It is involved in a fusion of homotypic membranes, protein degradation, and activation of membrane-bound transcription factors.

An Overview of p97

P97 is called VCP (valosin-containing protein) in animals and Cdc48p in yeast and this protein is a conserved protein in all eukaryotic cells, and it's a protein of Saccharomyces cerevisiae. It is essential for the development of Drosophila melanogaster and mice. The amount of p97 present in cells is huge. p97, which accounts for the total protein in a cell, is a ubiquitin selective molecular companion. Its main role is to open the folded protein and depolymerize the specific protein complex p97, and convert the chemical energy generated by ATP hydrolysis into mechanical energy to depolymerize and separate the target protein. P97 plays an important role in various processes and activities of cells. The functional diversity of P97 depends mainly on its binding to different cofactors and proteins.

Inhibition of p97

At present, there are 6 kinds of inhibitors of p97. is involved in the activation of oncogenes and inhibition of apoptosis of tumor cells, as well as tumor invasion, metastasis and immune response. Biological behaviors such as apoptosis are closely related to it. It is suggested that p97 plays an important role in the overexpression and iron uptake in human glioma cells. The iron-independent iron transport mediated by p97 may be the main pathway of iron uptake for glioma cells. The functions of this iron-independent transferrin-dependent iron transport system are as follows: first, iron uptake of cells involved in the absence or minimal expression of transferrin receptors on the surface; secondly, meeting the demand for iron of rapidly proliferating cells; and in the process of tumor cell metastasis, many enzymes were secreted to dissolve adjacent normal cells and a large amount of free iron p97 was released as a scavenger of free iron, which reduces the toxic effect of free radicals formed by free radicals on tumor cells. The tumor cells are further metastasized and proliferated.

Reference:

1. Xia, C., Chen, G., & Qian, Z. (2000). The role of p97 in iron metabolism in human brain glioma cells.Acta Academiae Medicinae Suzhou,20(4), 328-330.

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