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ZW4864- CAS

CAS No.:

ZW4864 is an Orally Bioavailable Small-Molecule Inhibitor for the β‑Catenin/B-Cell Lymphoma 9 Protein−Protein Interaction. ZW4864, that binds with β-catenin and selectively disrupts the protein−protein interaction (PPI) between B-cell lymphoma 9 (BCL9) and β-catenin while sparing the β-catenin/E-cadherin PPI. ZW4864 dose-dependently suppresses β-catenin signaling activation, downregulates oncogenic β-catenin target genes, and abrogates invasiveness of β-catenin-dependent cancer cells. More importantly, ZW4864 shows good pharmacokinetic properties and effectively suppresses β-catenin target gene expression in the patient-derived xenograft mouse model.

C33H43ClN6O3
PRODUCT  DETAILS
Synonyms:

ZW4864; ZW 4864; ZW-4864;

Molecular Formula:

C33H43ClN6O3

Molecular Weight:607.196
Cat No:I038786
Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Purity:98.0
Appearance:Solid powder
Price:Get quote

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For research use only. Not Intended for Therapeutic Use!

Product-Name:ZW4864
IUPAC Name:(R)-4-(2-(3-(3-((4-(1H-pyrazol-4-yl)benzyl)(cyclopropyl)carbamoyl)piperidin-1-yl)phenoxy)-2-methylpropanoyl)piperazin-1-ium chloride
InChI:InChI=1S/C33H42N6O3.ClH/c1-33(2,32(41)37-17-14-34-15-18-37)42-30-7-3-6-29(19-30)38-16-4-5-26(23-38)31(40)39(28-12-13-28)22-24-8-10-25(11-9-24)27-20-35-36-21-27;/h3,6-11,19-21,26,28,34H,4-5,12-18,22-23H2,1-2H3,(H,35,36);1H/t26-;/m1./s1
InChIKey:PQRRIGABHUYXRQ-UFTMZEDQSA-N
SMILES:O=C(N(C1CC1)CC2=CC=C(C3=CNN=C3)C=C2)[[email protected]@H]4CCCN(C5=CC(OC(C)(C)C(N6CC[NH2+]CC6)=O)=CC=C5)C4.[Cl-]
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