ZLY032 - CAS 2314465-67-1
ZLY032 is a dual agonist of free fatty acid receptor 1 and peroxisome proliferator-activated receptor δ. It is selective for FFAR1 and PPARδ over PPARα and PPARγ. ZLY032 reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease. It reduces hepatic steatosis and plasma alanine transaminase and aspartate aminotransferase levels in a mouse model of non-alcoholic steatohepatitis induced by a methionine and choline-deficient diet at the same dose.
Catalog Number: I038752
CAS Number: 2314465-67-1
Molecular Formula: C22H18F3NO4S
Molecular Weight:449.4442
Purity: 98.0%
Appearance:Solid powder
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | ZLY 032; ZLY-032; |
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Property
Molecular Formula: | C22H18F3NO4S |
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Molecular Weight | 449.4442 |
Solubility | Soluble in DMSO |
Purity | 98.0% |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Computed Descriptor
IUPAC Name | (S)-2-(6-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid |
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InChI | InChI=1S/C22H18F3NO4S/c1-12-19(31-21(26-12)13-2-4-15(5-3-13)22(23,24)25)11-29-16-6-7-17-14(8-20(27)28)10-30-18(17)9-16/h2-7,9,14H,8,10-11H2,1H3,(H,27,28)/t14-/m1/s1 |
InChIKey | YBBZJHLFUPKHJD-CQSZACIVSA-N |
SMILES | CC1=C(COC2=CC=C3[C@@H](COC3=C2)CC(O)=O)SC(C4=CC=C(C=C4)C(F)(F)F)=N1 |