YKL-5-124 - CAS 1957203-01-8

YKL-5-124(Cat No.:I014834) is a potent and selective inhibitor of cyclin-dependent kinase 7 (CDK7) with notable inhibitory activity. It demonstrates IC50 values of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 exhibits high selectivity for CDK7 over CDK9 and CDK2 (>100-fold), and it is inactive against CDK12 and CDK13. Treatment with YKL-5-124 leads to a robust cell-cycle arrest, inhibits E2F-driven gene expression, and has minimal impact on RNA polymerase II phosphorylation status.

Catalog Number: I014834

CAS Number: 1957203-01-8

Molecular Formula: C₂₈H₃₃N₇O₃

Molecular Weight:515.61

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Property

Molecular Formula: C₂₈H₃₃N₇O₃
Molecular Weight515.61
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC NameN-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[[4-(prop-2-enoylamino)benzoyl]amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide
InChIInChI=1S/C28H33N7O3/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37)/t22-/m1/s1
InChIKeyKPABJHHKKJIDGX-JOCHJYFZSA-N
SMILESCC1(C2=C(CN1C(=O)NC(CN(C)C)C3=CC=CC=C3)C(=NN2)NC(=O)C4=CC=C(C=C4)NC(=O)C=C)C