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Waglerin-1-FAM

Waglerin-1-FAM

  • CAT Number: P000395
  • Molecular Formula: C133H185N37O32S2
  • Purity: ≥95%
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Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of adult muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the adult nAChR subtypes.

Catalog Number P000395
Molecular Formula

C133H185N37O32S2

Purity 95%
Target Waglerin-1 blocks muscle nAChRs
Storage RT

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