UE2343

• CAT Number: I037799
• CAS Number: 1346013-80-6
• Molecular Formula: C19H19N5O2S
• Molecular Weight: 381.454
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone
• InChI: InChI=1S/C19H19N5O2S/c25-17(12-6-16(27-11-12)13-9-22-23-10-13)24-14-2-3-15(24)8-19(26,7-14)18-20-4-1-5-21-18/h1,4-6,9-11,14-15,26H,2-3,7-8H2,(H,22,23)/t14-,15+,19+
• InChIKey: MMZFGTAMARVHAF-QWHZDKJVSA-N
• SMILES: C(C1C=C(C2=CNN=C2)SC=1)(N1[C@@]([H])2CC[C@@]1([H])C[C@](O)(C1=NC=CC=N1)C2)=O

UE2343 (Xanamem) is a potent, orally bioavailable, brain-penetrant 11β-HSD1 inhibitor.

Reference

Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. PMID: 28012176; PMCID: PMC5301048.