UC-514321

• CAT Number: I017177
• CAS Number: 299420-83-0
• Molecular Formula: C₂₆H₃₅NO₅
• Molecular Weight: 441.56
• Purity: ≥95%
• IUPAC Name: 6-[(3,5-ditert-butyl-4-hydroxyphenyl)-morpholin-4-ylmethyl]-1,3-benzodioxol-5-ol
• InChI: InChI=1S/C26H35NO5/c1-25(2,3)18-11-16(12-19(24(18)29)26(4,5)6)23(27-7-9-30-10-8-27)17-13-21-22(14-20(17)28)32-15-31-21/h11-14,23,28-29H,7-10,15H2,1-6H3
• InChIKey: XNARHFDDQALZPZ-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(C2=CC3=C(C=C2O)OCO3)N4CCOCC4

UC-514321（Cat No.:I017177） is a potent inhibitor of the transcription factors STAT3/5 and suppresses the expression of the TET1 gene in acute myeloid leukemia (AML). It is a structural analog of NSC370284 and has a higher activity against AML cells in vitro and in vivo with low toxicity. UC-514321 directly binds to STAT3/5, inhibits their phosphorylation, and reduces their nuclear translocation, leading to the downregulation of downstream genes involved in AML pathogenesis.

Reference

[1]. Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.