Tianeptine

• CAT Number: I004707
• CAS Number: 72797-41-2
• Molecular Formula: C21H25ClN2O4S
• Molecular Weight: 436.95
• Purity: ≥95%
• Target: 5-HT Receptor
• Solubility: DMSO：≥ 4.5 mg/mL
• Storage: Store at -20C
• IC50: N/A

Tianeptine(CAT: I004707) is a medication used for the treatment of depression and anxiety disorders. Tianeptine is classified as an atypical antidepressant, and its exact mechanism of action is not fully understood. It is believed to work by enhancing the reuptake of serotonin and increasing the release of dopamine in the brain, leading to an improvement in mood.

Reference

[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20.
Abstract
Biochemical and behavioural experiments have indicated that the novel antidepressant tianeptine stimulates 5-hydroxytryptamine (5-HT) reuptake. The present study has explored the influence of acute tianeptine pretreatment upon corticosterone release and body weight loss following L-5-hydroxytryptophan (5-HTP) administration in conscious rats. Administration of 5-HTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min beforehand). Besides, prior administration of benserazide (50 mg/kg i.p., 30 min beforehand), an inhibitor of peripheral aromatic L-amino acid decarboxylase, prevented 5-HTP-induced corticosterone release in both saline- and tianeptine-pretreated rats. However, combined administration of benserazide and 5-HTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats. These results suggest that tianeptine preferentially activates 5-HT reuptake in central serotonergic neurones.