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Terazosin

Terazosin

  • CAT Number: A000034
  • CAS Number: 63074-08-8
  • Molecular Formula: C19H26ClN5O4
  • Molecular Weight: 423.898
  • Purity: ≥95%
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Terazosin is a potent and selective α<sub>1</sub>-adrenergic receptor (α<sub>1</sub>-AR) antagonist (K<sub>i</sub>s = 3.28, 0.68, and 1.09 for α<sub>1A</sub>-, α<sub>1B</sub>- and α<sub>1D</sub>-ARs, respectively). It is selective for α<sub>1</sub>- over α<sub>2</sub>-AR subtypes (K<sub>i</sub>s = 1,510, 7.71, and 78.2 nM for A<sub>2a</sub>-, A<sub>2b</sub>-, and A<sub>2c</sub>-ARs, respectively). Terazosin (0.1-30 mg/kg) decreases blood pressure in spontaneously hypertensive rats. It also decreases blood pressure in anesthetized dogs. Formulations containing terazosin are used to treat hypertension and benign prostatic hyperplasia.

Catalog Number A000034
CAS Number 63074-08-8
Molecular Formula

C19H26ClN5O4

Purity 95%
Storage -20°C
IUPAC Name [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;hydrochloride
InChI InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
InChIKey IWSWDOUXSCRCKW-UHFFFAOYSA-N
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.Cl

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