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TED-347

TED-347

  • CAT Number: I015533
  • CAS Number: 2378626-29-8
  • Molecular Formula: C₁₅H₁₁ClF₃NO
  • Molecular Weight: 313.7
  • Purity: ≥95%
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TED-347（Cat No.:I015533） is a potent and irreversible covalent allosteric inhibitor of the theTEAD⋅Yapprotein-protein interact. TED-347 inhibits TEAD4⋅Yap1 protein interaction with an EC50 value of 5.9 μM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Catalog Number I015533
CAS Number 2378626-29-8
Molecular Formula

C₁₅H₁₁ClF₃NO

Purity 95%
IUPAC Name 2-chloro-1-[2-[3-(trifluoromethyl)anilino]phenyl]ethanone
InChI InChI=1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2
InChIKey JPVDFGYNLUBCSD-UHFFFAOYSA-N
SMILES C1=CC=C(C(=C1)C(=O)CCl)NC2=CC=CC(=C2)C(F)(F)F
Reference

[1]. Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.

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