SB 205384

• CAT Number: I009308
• CAS Number: 160296-13-9
• Molecular Formula: C17H18N2O3S
• Molecular Weight: 330.402
• Purity: ≥95%
• Target: GABA Receptor
• Solubility: Soluble in DMSO
• Storage: Desiccate at RT
• IUPAC Name: but-2-ynyl 4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylate
• InChI: InChI=1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)
• InChIKey: JDTZAGLGBRRCJT-UHFFFAOYSA-N
• SMILES: CC#CCOC(=O)C1=C(N=C2C(=C1N)C3=C(S2)CC(CC3)O)C

SB 205384 is a GABAA receptor modulator. It potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). SB 205384 displays little effect on receptors containing α1 or α2 subunits.

Reference

1:SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. Heidelberg LS, Warren JW, Fisher JL.J Pharmacol Exp Ther. 2013 Oct;347(1):235-41. doi: 10.1124/jpet.113.207324. Epub 2013 Jul 31. PMID: 23902941 Free PMC Article2:Effects of SB-205384, a positive modulator of alpha3-subunit-containing GABA-A receptors, on isolation-induced aggression in male mice. Navarro JF, Burón E, Martín-López M.Psicothema. 2008 Feb;20(1):144-7. PMID: 18206077 3:Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice. Navarro JF, Burón E, Martín-López M.Psicothema. 2006 Feb;18(1):100-4. PMID: 17296016 4:SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity. Meadows HJ, Kumar CS, Pritchett DB, Blackburn TP, Benham CD.Br J Pharmacol. 1998 Mar;123(6):1253-9. PMID: 9559912 Free PMC Article5:Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Meadows HJ, Harries MH, Thompson M, Benham CD.Br J Pharmacol. 1997 Aug;121(7):1334-8. PMID: 9257911 Free PMC Article