Ruthenium Red

• CAT Number: R015986
• CAS Number: 11103-72-3
• Molecular Formula: Cl6H46N14O2Ru3
• Molecular Weight: 790.374
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: Soluble to 10 mM in sterile water
• Storage: Store at RT
• IUPAC Name: azane;ruthenium(2+);hexachloride;dihydrate
• InChI: InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
• InChIKey: JQJSTVUROJELSR-UHFFFAOYSA-H
• SMILES: N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]

Calcium antagonist; inhibitor of Ca2+/Mg2+ ATPase.Complex of Ruthenium elements,<!–Cl<SUB>6</SUB>H<SUB>42</SUB>N<SUB>14</SUB>O<SUB>2</SUB>Ru<SUB>3</SUB>–>, synthetic.As a calcium antagonist, its inhibitory mechanism differs from that of other antagonists [1]. Its selective interaction with Calmodulin may explain some of the following pharmacological actions: – inhibits Ca2+ uptake in mitochondria and Ca2+ release from sarcoplasmic reticulum in skeletal and cardiac muscles. – inhibits Ca2+-ATPase and ATP independent Ca2+ binding with rat heart sarcolemma. – prevents Capsaicin-induced transmitter release from primary afferent nerve terminals.

Reference

– Masuoka et al., /Effects of Ruthenium Red on Activation of Ca<SUP>2+</SUP>-dependent cyclic nucleotide phosphodiesterase./ <I>Biochem. Biophys. Res. Comm</I>. (1990). 169(1):315-322- Amman et al., /Capsaicin desensitization in vivo is inhibited by Ruthenium Red./ <I>Eur. J. Pharmacol</I>. (1990). 186(2-3):169- Amman et al., /Capsaicin-induced stimulation of polymodal nociceptors is antagonised by Ruthenium Red independently of extracellular calcium./ <I>Neuroscience</I> (1989). 32(1):255- Luthra et al., /The inhibition of calcium uptake and release by rat liver mitochondria by Ruthenium Red./ <I>FEBS Letters</I> (1977). 81(1):142