Rp-8-pCPT-cGMPS sodium - CAS 208445-07-2
PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.
Catalog Number: I011230
CAS Number: 208445-07-2
PubChem Substance ID:355200795
Molecular Formula: C16H14ClN5NaO6PS2
Molecular Weight:525.851
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3/’,5/’-[hydrogen [P(R)]-phosphorothioate] sodium |
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Property
Molecular Formula: | C16H14ClN5NaO6PS2 |
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Molecular Weight | 525.851 |
Target: | Broad Spectrum Protein Kinase Inhibitor |
Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
Purity | ≥95% |
Storage | Store at -20C |
Computed Descriptor
IUPAC Name | sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxo-2-sulfido-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one |
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InChI | InChI=1S/C16H15ClN5O6PS2.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(27-14)5-26-29(25,30)28-11;/h1-4,8,10-11,14,23H,5H2,(H,25,30)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-,29?;/m1./s1 |
InChIKey | JERAACMSJYSCBY-OZOPYAHTSA-M |
SMILES | C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=O)(O1)[S-].[Na+] |