PS-1145 - CAS 431898-65-6 (free base); 1049743-58-9 (dihydrchloride salt)
PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. PS1145 induced caspase 3/7-dependent apoptosis in PC cells and significantly sensitized PC cells to apoptosis induced by tumor necrosis factor alpha. PS1145 inhibited PC cell proliferation. PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats. PS1145 can overcome imatinib resistance.
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Catalog Number: I008893
CAS Number: 431898-65-6 (free base); 1049743-58-9 (dihydrchloride salt)
Molecular Formula: C17H11ClN4O
Molecular Weight:322.752
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | PS-1145; PS 1145; PS1145.;N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide |
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Property
| Molecular Formula: | C17H11ClN4O |
|---|---|
| Molecular Weight | 322.752 |
| Target: | IKK inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Purity | ≥95% |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |