PS-1145 - CAS 431898-65-6 (free base); 1049743-58-9 (dihydrchloride salt)
PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. PS1145 induced caspase 3/7-dependent apoptosis in PC cells and significantly sensitized PC cells to apoptosis induced by tumor necrosis factor alpha. PS1145 inhibited PC cell proliferation. PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats. PS1145 can overcome imatinib resistance.
* For research use only. Not for human or veterinary use.
|Synonyms||PS-1145; PS 1145; PS1145.;N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide|
|Solubility||Soluble in DMSO, not in water|
|Storage||0 - 4 °C for short term, or -20 °C for long term|