Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8(IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2

Catalog Number: P000365

Molecular Formula: C171H245N53O47S6

Molecular Weight:3987.50 Da

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Molecular Formula: C171H245N53O47S6
Molecular Weight3987.50 Da
Target:Blocker of voltage-gated sodium channels and T-type Cav