Pitavastatin Calcium

• CAT Number: A000464
• CAS Number: 147526-32-7
• Molecular Formula: [C25H24FNO4]2 • Ca
• Molecular Weight: 881
• Purity: ≥95%
• Target: HMG-CoA Reductase
• Solubility: >34.9mg/mL in DMSO
• Storage: 3 years -20C powder
• InChIKey: RHGYHLPFVJEAOC-FFNUKLMVSA-N

Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor.Pitavastatin significantly reduces both intracellular levels and synthesis of cholesterol esters. Pitavastatin is found to enhance LDL-receptor expression in vitro, as well as the amount of LDL binding to the LDL-receptor. Pitavastatin also exhibits more potent induction of LDL receptor mRNA expression compared with simvastatin and atorvastatin. Pitavastatin has many pleiotropic effects in vitro and in vivo, including deterring progression of atherosclerosis via inhibition of thromboxane synthesis, inhibition of migration/proliferation of vascular smooth muscle cells induced by angiotensin II, and stabilization of atherosclerotic plaque.Pitavastatin decreases the tumor growth and improved the survival of tumor-bearing mice