PD-0325901 - CAS 391210-10-9

PD-0325901(CAT: I003435) is a selective MEK1 and MEK2 inhibitor. PD-0325901 inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). At a PD0325901 dose of 20 to 25 mg/kg/day, complete suppression of tumor growth was observed in mice inoculated with PTC cells carrying a BRAF mutation within 1 week of PD0325901 treatment. This product is used in pharmaceutical research and development and other scientific research fields.

Catalog Number: I003435

CAS Number: 391210-10-9

PubChem Substance ID:355040728

Molecular Formula: C₁₆H₁₄F₃IN₂O₄

Molecular Weight:482.2

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsN-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

Property

Molecular Formula: C₁₆H₁₄F₃IN₂O₄
Molecular Weight482.2
Target:MEK1/2
SolubilityDMSO: ≥ 20 mg/mL, H2O: < 1 mg/mL
Purity≥95%
Storage3 years -20C powder
MDLMFCD08435926

Computed Descriptor

InChIInChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
InChIKeySUDAHWBOROXANE-SECBINFHSA-N
SMILESC1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O