Padoporfin (Tookad)

• CAT Number: I008542
• CAS Number: 274679-00-4
• Molecular Formula: C35H38N4O6Pd
• Molecular Weight: 717.131
• Purity: ≥95%
• Solubility: Soluble in DMSO, not soluble in water.
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C35H38N4O6.Pd/c1-8-19-14(2)21-13-26-28(18(6)40)16(4)23(37-26)11-22-15(3)20(9-10-27(41)42)32(38-22)30-31(35(44)45-7)34(43)29-17(5)24(39-33(29)30)12-25(19)36-21;/h11-15,19-20,31,37,39H,8-10H2,1-7H3,(H,41,42);/t14-,15+,19-,20+,31-;/m1./s1
• InChIKey: XFLDLTRMWUFLPY-GDUCSYRESA-N
• SMILES: CCC1C(C2=NC1=CC3=C(C4=C(N3)C(=C5C(C(C(=N5)C=C6C(=C(C(=C2)N6)C(=O)C)C)C)CCC(=O)O)C(C4=O)C(=O)OC)C)C.[Pd]

Padoporfin (Cat. No: I008542) is a new faster photosensitizer. During the treatment, Padoporfin is delivered to the tumor site by a specially designed fiber injection placed in the prostate, and then padoporfin is activated by a certain wavelength of light, further cutting off the blood and oxygen supply of the surrounding tissue of cancer, thereby killing the tumor.

Reference

1:Madar-Balakirski N, Tempel-Brami C, Kalchenko V, Brenner O, Varon D, Scherz A, Salomon Y. Permanent occlusion of feeding arteries and draining veins in solid mouse tumors by vascular targeted photodynamic therapy (VTP) with Tookad. PLoS One. 2010 Apr 22;5(4):e10282. PubMed PMID: 20421983; PubMed Central PMCID: PMC2858664. 2: