Niclosamide ethanolamine salt

• CAT Number: M050574
• CAS Number: 1420-04-8
• Molecular Formula: C15H15Cl2N3O5
• Molecular Weight: 388.201
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 2-aminoethanol;5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
• InChI: InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2
• InChIKey: XYCDHXSQODHSLG-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O.C(CO)N

Niclosamide (Item No. 10649) is an antihelminthic compound that affects mitochondrial metabolism in parasitic worms. It specifically inhibits the signal transducer and activator of transcription 3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mTORC1 signaling (complete inhibition of S6K phosphorylation at 3 μM). Niclosamide ethanolamine is a more water soluble, salt version of niclosamide that has been used to increase energy expenditure and lipid metabolism in mice. At 125 mg/kg/day, niclosamide ethanolamine prevented high-fat diet-induced hepatic steatosis and insulin resistance and improved glycemic control in db/db mice.