Necrostatin 2 racemate - CAS 852391-15-2

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
IC50 Value: 50 nM (EC50) [1]
Target: TNF-alpha
Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

Catalog Number: I013923

CAS Number: 852391-15-2

PubChem Substance ID:355049840

Molecular Formula: C₁₃H₁₂ClN₃O₂

Molecular Weight:277.71

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Property

Molecular Formula: C₁₃H₁₂ClN₃O₂
Molecular Weight277.71
Target: TNF-alpha
Solubility10 mM in DMSO
Purity≥95%

Computed Descriptor

IUPAC Name5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
InChIInChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
InChIKeyWIKGAEMMNQTUGL-UHFFFAOYSA-N
SMILESCN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl