Nec-4 - CAS 1041644-43-2

Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.

Catalog Number: I019986

CAS Number: 1041644-43-2

Molecular Formula: C₁₅H₁₃ClFN₃O

Molecular Weight:305.73

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Molecular Formula: C₁₅H₁₃ClFN₃O
Molecular Weight305.73