MRT67307 - CAS 1190378-57-4

MRT67307(CAT: I000690)is a dual inhibitor of IKKe (IκB kinase epsilon) and TBK-1 (TANK-binding kinase 1). By inhibiting these kinases, MRT67307 effectively prevents the phosphorylation of IRF3 (interferon regulatory factor 3) and subsequently inhibits the production of IFN-β (interferon beta). In addition, MRT67307 has been shown to increase the secretion of anti-inflammatory cytokines such as IL-10 (interleukin-10) and IL-1ra (interleukin-1 receptor antagonist) in macrophages upon stimulation of toll-like receptors. These pharmacological effects suggest that MRT67307 has potential therapeutic applications in modulating immune responses and inflammation-related diseases.

Catalog Number: I000690

CAS Number: 1190378-57-4

PubChem Substance ID:349242957

Molecular Formula: C26H36N6O2

Molecular Weight:464.6

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsN-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide

Property

Molecular Formula: C26H36N6O2
Molecular Weight464.6
Target:IκB/IKK
Solubilityin DMSO > 10 mM
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC NameN-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
InChIInChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
InChIKeyUKBGBACORPRCGG-UHFFFAOYSA-N
SMILESO=C(C1CCC1)NCCCNC2=NC(NC3=CC(CN4CCOCC4)=CC=C3)=NC=C2C5CC5