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MRIA9

MRIA9 is a Selective Salt-Inducible Kinase Inhibitor. MRIA9 showed dual SIK/PAK activity and excellent selectivity over other kinases. MRIA9 sensitizes ovarian cancer cells to treatment with the mitotic agent paclitaxel, confirming earlier data from genetic knockdown studies and suggesting a combination therapy with SIK inhibitors and paclitaxel for the treatment of paclitaxel-resistant ovarian cancer.

Catalog Number: I032765

Molecular Formula: C24H22ClFN6O3

Molecular Weight:496.9274

Purity: 98.0%

Appearance:Solid powder

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Synonym

SynonymsMRIA9; MRIA 9; MRIA-9;

Property

Molecular Formula: C24H22ClFN6O3
Molecular Weight496.9274
SolubilityTo be determined
Purity98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Computed Descriptor

IUPAC Name8-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(3-fluoropyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChIInChI=1S/C24H22ClFN6O3/c1-28-24-30-9-14-7-17(16-5-4-13(8-18(16)25)21-19(26)3-2-6-29-21)23(33)32(22(14)31-24)10-20-34-11-15(27)12-35-20/h2-9,15,20H,10-12,27H2,1H3,(H,28,30,31)/t15-,20-
InChIKeyQKNBRNSGPNCARD-SGNKCFNYSA-N
SMILESO=C1C(C2=CC=C(C3=NC=CC=C3F)C=C2Cl)=CC4=CN=C(NC)N=C4N1C[C@H]5OC[C@H](N)CO5