Monastrol - CAS 254753-54-3

Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.

Catalog Number: I007884

CAS Number: 254753-54-3

PubChem Substance ID:355036700

Molecular Formula: C14H16N2O3S

Molecular Weight:292.35

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsMonastrol;ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Property

Molecular Formula: C14H16N2O3S
Molecular Weight292.35
Target:Kinesin
SolubilitySoluble in DMSO, not in water
Purity≥95%
StorageStore at -20C

Computed Descriptor

InChIInChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChIKeyLOBCDGHHHHGHFA-UHFFFAOYSA-N
SMILESO=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC