Monastrol - CAS 254753-54-3
Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.
Catalog Number: I007884
CAS Number: 254753-54-3
PubChem Substance ID:355036700
Molecular Formula: C14H16N2O3S
Molecular Weight:292.35
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | Monastrol;ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
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Property
Molecular Formula: | C14H16N2O3S |
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Molecular Weight | 292.35 |
Target: | Kinesin |
Solubility | Soluble in DMSO, not in water |
Purity | ≥95% |
Storage | Store at -20C |
Computed Descriptor
InChI | InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20) |
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InChIKey | LOBCDGHHHHGHFA-UHFFFAOYSA-N |
SMILES | O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC |