MMP-3 Inhibitor VIII - CAS 208663-26-7
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.
Catalog Number: R065494
CAS Number: 208663-26-7
PubChem Substance ID:355181852
Molecular Formula: C20H26N2O5S
Molecular Weight:406.497
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | Matrix Metalloproteinase-3 Inhibitor VIII;Stromelysin-1 Inhibitor VIII |
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Property
Molecular Formula: | C20H26N2O5S |
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Molecular Weight | 406.497 |
Purity | ≥95% |
Storage | -20°C |
Computed Descriptor
IUPAC Name | 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-N-hydroxy-4-methylpentanamide |
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InChI | InChI=1S/C20H26N2O5S/c1-15(2)13-19(20(23)21-24)22(14-16-7-5-4-6-8-16)28(25,26)18-11-9-17(27-3)10-12-18/h4-12,15,19,24H,13-14H2,1-3H3,(H,21,23) |
InChIKey | VKUYLANQOAKALN-UHFFFAOYSA-N |
SMILES | CC(C)CC(C(=O)NO)N(CC1=CC=CC=C1)S(=O)(=O)C2=CC=C(C=C2)OC |